COMPUTATIONAL STUDY OF GEOMETRIC EFFECTS OF BOTTOM WALL MICROGROOVES ON CELL DOCKING INSIDE MICROFLUIDIC DEVICES

Cells docking inside microfluidic devices is effective in studying cell biology, cell-based biosensing, as well drug screening. Furthermore, single and regularly cells the microstructure of systems are advantageous different analyses exposed to equal concentration mechanical stimulus. In this study, we investigated bottom wall microgrooves with semicircular rectangular geometries sizes which suitable for along length microgroove [Formula: see text]-direction numerous one line a 3D microchannel. We used computational fluid dynamics analyze recirculation area microgrooves. The height could affect cell’s attachment, also materials delivery attached cells, so may have optimum value. addition, analyzed drag force on movement toward microgroove. This parameter was proportional velocities text] directions geometries. microgrooves’ velocity did not change, but decreased Therefore, time increased, push due lower text]-direction. percentages negative shear stress average adhered surface were calculated. stress, around 50% against detachment from substrate. results indicated that at constant inlet microchannel height, geometry ratio size play pivotal roles initial adhesion substrate detachment.